TGFBR1 Protein (AA 27-126) (hIgG-His-tag)

N° du produit ABIN5855082

Détail du produit

Antigène: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Type de proteíne: Recombinant

Attributs du protein: AA 27-126

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette TGFBR1 protéine est marqué à la hIgG-His-tag.

Application: SDS-PAGE (SDS)

Séquence: ADLLLPGATA LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT TVKSSPGLGP VELVEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH

Pureté: > 90 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Autre désignation: TGFBR1 (TGFBR1 Produits)

Synonymes: AAT5 Protein, ACVRLK4 Protein, ALK-5 Protein, ALK5 Protein, LDS1A Protein, LDS2A Protein, MSSE Protein, SKR4 Protein, TGFR-1 Protein, aat5 Protein, acvrlk4 Protein, alk-5 Protein, alk5 Protein, lds1a Protein, lds2a Protein, skr4 Protein, tgfr-1 Protein, TGFBR1 Protein, x-trr1 Protein, AU017191 Protein, Alk-5 Protein, TbetaR-I Protein, TbetaRI Protein, Alk5 Protein, Skr4 Protein, Tgfr-1 Protein, tbetaR-I Protein, tgfbr1 Protein, zgc:123263 Protein, transforming growth factor beta receptor 1 Protein, transforming growth factor beta receptor I Protein, transforming growth factor beta receptor I S homeolog Protein, transforming growth factor, beta receptor I Protein, transforming growth factor, beta receptor 1 Protein, transforming growth factor, beta receptor 1 a Protein, TGFBR1 Protein, tgfbr1 Protein, tgfbr1.S Protein, Tgfbr1 Protein, tgfbr1a Protein

Sujet: TGFBR1, also known as TGF-beta receptor type-1 isoform 1, is a single-pass type 1 membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. This protein is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. Also, it plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Diets syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5). Recombinant human TGFBR1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 38.0kDa (342aa) 40-57kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_004603

UniProt: P36897

Pathways: Growth Factor Binding