B7-H6 Protein (AA 25-262) (Fc Tag)

N° du produit ABIN6253446

Détail du produit

Antigène: B7-H6 (NCR3LG1) (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1))

Type de proteíne: Recombinant

Attributs du protein: AA 25-262

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette B7-H6 protéine est marqué à la Fc Tag.

Fonction: B7-H6 (human):Fc (mouse) (rec.)

Specificité: The extracellular domain of human B7-H6 (aa 25-262) is fused to the N-terminus of the Fc region of mouse IgG2a.

Attributs du produit: Protein. The extracellular domain of human B7-H6 (aa 25-262) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.

Pureté: >98 % (SDS-PAGE)

niveau d'endotoxine: <5EU/mg protein (LAL test, Lonza).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Détail du antigène

Antigène: B7-H6 (NCR3LG1) (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1))

Autre désignation: B7-H6 (NCR3LG1 Produits)

Synonymes: B7-H6 Protein, B7H6 Protein, DKFZp686O24166 Protein, natural killer cell cytotoxicity receptor 3 ligand 1 Protein, NCR3LG1 Protein

Sujet:

Product Description: B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.

Poids moléculaire: ~80kDa (SDS-PAGE)

NCBI Accession: NP_001189368