Dickkopf-related protein 1, also known as Dkk-1, is a member of the Dkk protein family including Dkk-1, 2, 3 and -4. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated level of Dkk-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Recombinant human Dkk-1 protein, fused to His-tag at C-terminus, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography. Synonyms: Dickkopf-1, hDkk-1, SK, Dickkopf-related protein 1 Dickkopf 1, Dickkopf 1 like, Dickkopf homolog 1, Dickkopf related protein 1, DKK 1, hDkk 1, DKK1. NCBI no.: NP_036374
Poids moléculaire
27.8 kDa (253 aa) (Molecular weight on SDS-PAGE will appear higher)