PRNP Protein (His tag)

N° du produit ABIN6387149

Détail du produit

Antigène: PRNP (Prion Protein (PRNP))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PRNP protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Pureté: > 90 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: Prion protein preproprotein, ASCR, CD230, CJD, GSS, MGC26679, prion, PRIP, PrP, PrP27-30, PrP33-35C, PrPc

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 1 M Urea, 10% glycerol

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: PRNP (Prion Protein (PRNP))

Autre désignation: PRNP (PRNP Produits)

Synonymes: ASCR Protein, AltPrP Protein, CD230 Protein, CJD Protein, GSS Protein, KURU Protein, PRIP Protein, PrP Protein, PrP27-30 Protein, PrP33-35C Protein, PrPc Protein, p27-30 Protein, Prn Protein, Prn-p Protein, prp Protein, cjd Protein, prion Protein, prp(c) Protein, MGC84114 Protein, PRP Protein, PRPC Protein, Prp Protein, SIP Protein, PRNP Protein, AA960666 Protein, AI325101 Protein, PrP Protein, PrPC Protein, PrPSc Protein, Prn-i Protein, Sinc Protein, prP27-30 Protein, prP33-35C Protein, PrP-1 Protein, PrP1 Protein, prnprs1 Protein, stPrP-1 Protein, zgc:123004 Protein, prion protein Protein, prion protein S homeolog Protein, prion protein b Protein, PRNP Protein, Prnp Protein, prnp.S Protein, prnpb Protein

Sujet: Prion protein, also known as PRNP, is a ubiquitous membrane glycoprotein whose abnormal self-replicating, misfolded form is widely believed to cause several central nervous system disorders, collectively known as Transmissible Spongiform Encephalopathies (TSE). This protein contains a highly unstable region of five tandem octapeptide repeat. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Recombinant human PRNP protein, fused to His-tag at N-terminus, was expressed in E.coli.

Poids moléculaire: 25 kDa (229aa)

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation