POLD4 Protein (AA 1-107) (His tag)

N° du produit ABIN6387269

Détail du produit

Antigène: POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4))

Type de proteíne: Recombinant

Attributs du protein: AA 1-107

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette POLD4 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMGRKRLI TDSYPVVKRR EGPAGHSKGE LAPELGEEPQ PRDEEEAELE LLRQFDLAWQ YGPCTGITRL QRWCRAKQMG LEPPPEVWQV LKTHPGDPRF QCSLWHLYPL

Pureté: > 90 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.2M NaCl, 40 % glycerol, 2  mM DTT

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4))

Autre désignation: POLD4 (POLD4 Produits)

Synonymes: 2410012M21Rik Protein, AI463381 Protein, AW060307 Protein, Polds Protein, p12 Protein, POLDS Protein, DNA polymerase delta 4, accessory subunit Protein, polymerase (DNA-directed), delta 4 Protein, POLD4 Protein, Pold4 Protein

Sujet: POLD4 is the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Recombinant human POLD4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 14.8 kDa (130aa) confirmed by MALDI-TOF

NCBI Accession: NP_066996

UniProt: Q9HCU8

Pathways: Telomere Maintenance, Réparation de l'ADN, DNA Replication, Synthesis of DNA