JTB Protein (AA 31-105) (His tag)
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- Antigène Voir toutes JTB Protéines
- JTB (Jumping Translocation Breakpoint (JTB))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 31-105
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette JTB protéine est marqué à la His tag.
- Application
- SDS-PAGE (SDS)
- Séquence
- MGSSHHHHHH SSGLVPRGSH MGSEAPVQEE KLSASTSNLP CWLVEEFVVA EECSPCSNFR AKTTPECGPT GYVEKITCSS SKRNEFKSCR SALMEQRL
- Pureté
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product JTB Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 10 % glycerol, 1 mM DTT
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Antigène
- JTB (Jumping Translocation Breakpoint (JTB))
- Autre désignation
- JTB (JTB Produits)
- Synonymes
- HJTB Protein, HSPC222 Protein, PAR Protein, hJT Protein, Gm622 Protein, JTB Protein, jumping translocation breakpoint Protein, JTB Protein, Jtb Protein
- Sujet
- Jumping translocation breakpoint, also known as JTB, is required for normal cytokinesis during mitosis. This protein plays a role in the regulation of cell proliferation. This protein may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. It lnhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. Recombinant human JTB protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Poids moléculaire
- 10.7 kDa (98aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_006685
- UniProt
- O76095
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