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IL1R2 Protein (AA 14-343) (His tag)

IL1R2 Origine: Humain Hôte: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS Active
N° du produit ABIN7281332
  • Antigène Voir toutes IL1R2 Protéines
    IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 14-343
    Origine
    • 18
    • 9
    • 4
    • 1
    • 1
    • 1
    Humain
    Source
    • 14
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Baculovirus infected Insect Cells
    Purification/Conjugué
    Cette IL1R2 protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
    Séquence
    FTLQPAAHTG AARSCRFRGR HYKREFRLEG EPVALRCPQV PYWLWASVSP RINLTWHKND SARTVPGEEE TRMWAQDGAL WLLPALQEDS GTYVCTTRNA SYCDKMSIEL RVFENTDAFL PFISYPQILT LSTSGVLVCP DLSEFTRDKT DVKIQWYKDS LLLDKDNEKF LSVRGTTHLL VHDVALEDAG YYRCVLTFAH EGQQYNITRS IELRIKKKKE ETIPVIISPL KTISASLGSR LTIPCKVFLG TGTPLTTMLW WTANDTHIES AYPGGRVTEG PRQEYSENNE NYIEVPLIFD PVTREDLHMD FKCVVHNTLS FQTLRTTVKE LEHHHHHH
    Pureté
    > 90 % by SDS - PAGE
    niveau d'endotoxine
    < 1.0 EU per 1ug of protein (determined by LAL method)
    Biological Activity Comment
    Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 for this effect is less or equal to 400 ng/ml with IL-1beta.
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    Discover our top product IL1R2 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Bioactivity Validated

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Antigène
    IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
    Autre désignation
    IL1R2 (IL1R2 Produits)
    Synonymes
    CD121b Protein, CDw121b Protein, IL-1R-2 Protein, IL-1RT-2 Protein, IL-1RT2 Protein, IL1R2c Protein, IL1RB Protein, Il1r-2 Protein, IL-1R2 Protein, interleukin 1 receptor type 2 Protein, interleukin 1 receptor, type II Protein, interleukin-like Protein, IL1R2 Protein, Il1r2 Protein, KK34 Protein
    Sujet
    IL1R2, also known as interleukin-1 receptor type 2 isoform 1, is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is expressed predominantly by, T cells, fibroblasts and endothelial cells. It binds interleukin-1 alpha (IL1A), interleukin-1beta (IL1B), and interleukin 1 receptor antagonist (IL1RN), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. Also, Interleukin-4 (IL4) is reported to antagonize the activity of interleukin-1 by inducing the expression and release of this cytokine. Recombinant human IL1R2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
    Poids moléculaire
    38.8kDa (338aa) 40-57kDa (SDS-PAGE under reducing conditions)
    NCBI Accession
    NP_004624
    UniProt
    P27930
    Pathways
    Signalisation NF-kappaB
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