UBE2N Protein (AA 1-152) (His tag)

N° du produit ABIN666632

Détail du produit

Antigène: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Type de proteíne: Recombinant

Attributs du protein: AA 1-152

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette UBE2N protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: UBE2N, 1-152aa, Human, His tag, E.coli

Pureté: > 95 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, Q10010.1M NaCl,1mM DTT

Stock: 4 °C

Détail du antigène

Antigène: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Autre désignation: UBE2N (UBE2N Produits)

Synonymes: UBC13 Protein, UbcH-ben Protein, UbcH13 Protein, 1500026J17Rik Protein, AL022654 Protein, BB101821 Protein, ube2n Protein, wu:fb11b03 Protein, wu:fc08b06 Protein, zgc:55726 Protein, ubc13 Protein, ubch-ben Protein, UBE2N Protein, ube2nl Protein, zgc:63901 Protein, ubiquitin conjugating enzyme E2 N Protein, ubiquitin-conjugating enzyme E2N Protein, ubiquitin conjugating enzyme E2 N S homeolog Protein, ubiquitin-conjugating enzyme E2Na Protein, ubiquitin-conjugating enzyme E2Nb Protein, UBE2N Protein, Ube2n Protein, ube2n.S Protein, ube2na Protein, LOC100533434 Protein, ube2n Protein, ube2nb Protein

Sujet: UBE2N, also known as UBC13, is a member of the E2 ubiquitin-conjugating enzyme family. It catalyzes the ATP-dependent synthesis of non-canonical polyubiquitin chains, a process that does not lead to proteasomal degradation. It mediates the transcription of several target genes and is thought to play a role in cell cycle progression, cellular differentiation and DNA repair mechanisms that ensure cell survival after DNA damage. Recombinant human UBE2N protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Ubiquitin-conjugating enzyme E2 N, MGC131857, MGC8489, UBC13, UbcH-ben. NCBI no.: NP_003339

Poids moléculaire: 19.3 kDa(172aa), confirmed by MALDI-TOF

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway