14-3-3 sigma/SFN Protein (AA 1-248)

N° du produit ABIN666918

Détail du produit

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Type de proteíne: Recombinant

Attributs du protein: AA 1-248

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Attributs du produit: 14-3-3 sigma, 1-248aa, Human, E.coli

Pureté: > 95 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol

Stock: 4 °C

Détail du antigène

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Autre désignation: 14-3-3 sigma (SFN Produits)

Synonymes: YWHAS Protein, Er Protein, Mme1 Protein, Ywhas Protein, stratifin Protein, SFN Protein, Sfn Protein

Sujet: 14-3-3 sigma ,also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Recombinant human 14-3-3 sigma was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: stratifin, Epithelial cell marker protein 1, HME1, YWHAS, SFN, 14-3-3 sigma. NCBI no.: NP_006133

Poids moléculaire: 27.7 kDa (248aa), confirmed by MALDI-TOF.

Pathways: Signalisation p53, Myometrial Relaxation and Contraction