FLT3 Protein (AA 27-543) (Fc Tag)

N° du produit ABIN6809860

Détail du produit

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 27-543

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette FLT3 protéine est marqué à la Fc Tag.

Séquence: AA 27-543

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: Flt-3 (FLT3 Produits)

Synonymes: FLT3 Protein, B230315G04 Protein, CD135 Protein, Flk-2 Protein, Flk2 Protein, Flt-3 Protein, Ly72 Protein, wmfl Protein, FLK-2 Protein, FLK2 Protein, STK1 Protein, fms related tyrosine kinase 3 Protein, FMS-like tyrosine kinase 3 Protein, fms-related tyrosine kinase 3 Protein, FLT3 Protein, Flt3 Protein

Sujet: Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Poids moléculaire: 84.8 kDa

NCBI Accession: NP_004110

Pathways: Signalisation RTK