TNFRSF13C Protein (mFc Tag)

N° du produit ABIN6961114

Détail du produit

Antigène: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette TNFRSF13C protéine est marqué à la mFc Tag.

Application: ELISA

Fonction: Recombinant Human BAFF-R protein with C-terminal mouse Fc

Specificité: BAFF-R (Ser7-Ala71) mFc (Pro99-Lys330)

Attributs du produit: Extracellular Domain Protein

Purification: affinity purification

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Biological Activity Comment: EC50=109.8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Agent conservateur: Without preservative

Stock: -20 °C,-80 °C

Date de péremption: 12 months

Détail du antigène

Antigène: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Autre désignation: BAFF-R (TNFRSF13C Produits)

Synonymes: RGD1560810 Protein, TNFRSF13C Protein, BAFF-R Protein, BAFFR Protein, BROMIX Protein, CD268 Protein, CVID4 Protein, prolixin Protein, 2010006P15Rik Protein, Baffr Protein, Bcmd Protein, Bcmd-1 Protein, Bcmd1 Protein, Lvis22 Protein, TNF receptor superfamily member 13C Protein, uncharacterized LOC746611 Protein, tumor necrosis factor receptor superfamily, member 13c Protein, TNFRSF13C Protein, Tnfrsf13c Protein, LOC746611 Protein

Sujet: Synonymes: BAFFR,TNFRSF13C,BAFF-R,BROMIX,CD268,CVID4,prolixin
Description: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

Poids moléculaire: predicted molecular mass of 33.6 kDa after removal of the signal peptide.The apparent molecular mass of BAFF-R-mFc is 35-55 kDa due to glycosylation.

ID gène: 115650

UniProt: Q96RJ3

Pathways: Signalisation NF-kappaB