TNFRSF13C Protein (AA 10-71) (Fc Tag)

N° du produit ABIN5526590

Détail du produit

Antigène: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 10-71

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette TNFRSF13C protéine est marqué à la Fc Tag.

Séquence: AA 10-71

Attributs du produit: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 33.3 kDa. As a result of glycosylation, the protein migrates as 40-45 kDa under reducing (R) condition, and 80-100 kDa under non-reducing (NR) condition (SDS-PAGE).

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Autre désignation: BAFFR (TNFRSF13C Produits)

Synonymes: RGD1560810 Protein, TNFRSF13C Protein, BAFF-R Protein, BAFFR Protein, BROMIX Protein, CD268 Protein, CVID4 Protein, prolixin Protein, 2010006P15Rik Protein, Baffr Protein, Bcmd Protein, Bcmd-1 Protein, Bcmd1 Protein, Lvis22 Protein, TNF receptor superfamily member 13C Protein, uncharacterized LOC746611 Protein, tumor necrosis factor receptor superfamily, member 13c Protein, TNFRSF13C Protein, Tnfrsf13c Protein, LOC746611 Protein

Sujet: BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Poids moléculaire: 33.3 kDa

NCBI Accession: NP_082351

Pathways: Signalisation NF-kappaB