CXCR2 Protein (Fc Tag)

N° du produit ABIN6964253

Détail du produit

Antigène: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CXCR2 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human CXCR2 with C-terminal human Fc tag

Specificité: CXCR2 (Met1-Lys48) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: affinity purification

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Agent conservateur: Without preservative

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Autre désignation: CXCR2 (CXCR2 Produits)

Synonymes: CD182 Protein, CDw128b Protein, CMKAR2 Protein, IL8R2 Protein, IL8RA Protein, IL8RB Protein, CXC-R2 Protein, CXCR-2 Protein, CD128 Protein, CDw128 Protein, Cmkar2 Protein, Gpcr16 Protein, IL-8Rh Protein, IL-8rb Protein, Il8rb Protein, mIL-8RH Protein, C-X-C motif chemokine receptor 2 Protein, chemokine (C-X-C motif) receptor 2 Protein, Cxcr2 Protein, CXCR2 Protein

Sujet: Synonymes: CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Description: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Poids moléculaire: predicted molecular mass of 31.7 kDa after removal of the signal peptide. The apparent molecular mass of CXCR2-hFc is 35-55 kDa due to glycosylation.

UniProt: P25025

Pathways: cAMP Metabolic Process