CXCR2 Protéine

N° du produit ABIN7491621

Détail du produit

Antigène: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Type de proteíne: Synthetic

Origine: Humain

Source: HEK-293 Cells

Fonction: Human CXCR2 full length protein-synthetic nanodisc

Attributs du produit: Full Length Transmembrane Proteins (synthetic Nanodisc)

Information d'application

Indications d'application:

• Applications for VLPs:
• ELISA
• SPR affinity analysis
• Phage display screening
• Immunization
• Cell based assays
• CAR-T cell screening
• Protein cystal structure analysis

Commentaires:

Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Autre désignation: CXCR2 (CXCR2 Produits)

Synonymes: CD182 Protein, CDw128b Protein, CMKAR2 Protein, IL8R2 Protein, IL8RA Protein, IL8RB Protein, CXC-R2 Protein, CXCR-2 Protein, CD128 Protein, CDw128 Protein, Cmkar2 Protein, Gpcr16 Protein, IL-8Rh Protein, IL-8rb Protein, Il8rb Protein, mIL-8RH Protein, C-X-C motif chemokine receptor 2 Protein, chemokine (C-X-C motif) receptor 2 Protein, Cxcr2 Protein, CXCR2 Protein

Sujet: CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Description: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Poids moléculaire: The human full length CXCR2 protein has a MW of 40.8 kDa

UniProt: P25025

Pathways: cAMP Metabolic Process