ERG Protein (Fc Tag)

N° du produit ABIN6964259

Détail du produit

Antigène: ERG (ERG, ETS transcription factor (ERG))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ERG protéine est marqué à la Fc Tag.

Séquence: ERG(Val280-Glu405)+hFc(Glu99-Ala330)

Attributs du produit: Tagged Protein: C-Human Fc tag

Purification: affinity purification

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Agent conservateur: Without preservative

Stock: -80 °C

Stockage commentaire: Store at -80°C for 12 months (Avoid repeated freezing and thawing)

Date de péremption: 12 months

Détail du antigène

Antigène: ERG (ERG, ETS transcription factor (ERG))

Autre désignation: ERG (ERG Produits)

Synonymes: erg-3 Protein, p55 Protein, erg Protein, erg_A Protein, zgc:103429 Protein, erg_E Protein, ERG Protein, D030036I24Rik Protein, KCNH2 Protein, ERG, ETS transcription factor Protein, v-ets avian erythroblastosis virus E26 oncogene homolog L homeolog Protein, v-ets avian erythroblastosis virus E26 oncogene homolog Protein, v-ets avian erythroblastosis virus E26 oncogene homolog S homeolog Protein, ETS transcription factor Protein, potassium voltage-gated channel subfamily H member 6 Protein, ERG Protein, Erg Protein, erg.L Protein, erg Protein, erg.S Protein, KCNH6 Protein

Sujet: Synonymes: erg-3, p55
Description: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

Poids moléculaire: 49.39 kDa

UniProt: P11308