CD33 Protein (CD33) (AA 18-259) (His tag,FITC)
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- Antigène Voir toutes CD33 Protéines
- CD33
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 18-259
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD33 protéine est marqué à la His tag,FITC.
- Séquence
- AA 18-259
- Attributs du produit
- FITC-Labeled Human Siglec-3 / CD33 Protein, Fc Tag
- Pureté
- >90 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CD33 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -20 °C
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- Antigène
- CD33
- Autre désignation
- Siglec-3 (CD33 Produits)
- Synonymes
- SIGLEC-3 Protein, SIGLEC3 Protein, p67 Protein, Siglec-3 Protein, gp67 Protein, CD33 molecule Protein, CD33 antigen Protein, CD33 Protein, Cd33 Protein
- Sujet
- Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
- Poids moléculaire
- 27.6 kDa
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