IL2RG Protein (AA 23-254) (His tag)

N° du produit ABIN6992411

Détail du produit

Antigène: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Type de proteíne: Recombinant

Attributs du protein: AA 23-254

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IL2RG protéine est marqué à la His tag.

Fonction: Human IL-2 R gamma / CD132 Protein, His Tag (MALS verified)

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Autre désignation: IL-2 R gamma (IL2RG Produits)

Synonymes: Ab2-183 Protein, Cd132 Protein, CD132 Protein, CIDX Protein, IL-2RG Protein, IMD4 Protein, P64 Protein, SCIDX Protein, SCIDX1 Protein, [g]c Protein, gamma(c) Protein, gc Protein, interleukin 2 receptor subunit gamma Protein, interleukin 2 receptor subunit gamma L homeolog Protein, interleukin 2 receptor, gamma chain Protein, IL2RG Protein, il2rg.L Protein, Il2rg Protein

Sujet: IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

Poids moléculaire: 29.3 kDa

Pathways: Signalistation JAK/STAT, Growth Factor Binding