CD3G Protein (AA 23-116) (Fc Tag)

N° du produit ABIN7013164

Détail du produit

Antigène: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Type de proteíne: Recombinant

Attributs du protein: AA 23-116

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD3G protéine est marqué à la Fc Tag.

Attributs du produit: Human CD3 gamma / CD3G Protein, Fc Tag (MALS verified)

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: MALS verified

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Autre désignation: CD3 gamma (CD3G Produits)

Synonymes: Ctg-3 Protein, Ctg3 Protein, T3g Protein, CD3-GAMMA Protein, T3G Protein, CD3 antigen, gamma polypeptide Protein, CD3g molecule Protein, Cd3g Protein, CD3G Protein

Sujet: CD3 gamma chain is part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.

Poids moléculaire: 37.1 kDa

Pathways: TCR Signaling, CXCR4-mediated Signaling Events