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FAP Protein (AA 26-760) (His tag)

FAP Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN7013467
  • Antigène Voir toutes FAP Protéines
    FAP (Fibroblast Activation Protein, alpha (FAP))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 26-760
    Origine
    • 17
    • 10
    • 3
    • 3
    Humain
    Source
    • 17
    • 6
    • 4
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette FAP protéine est marqué à la His tag.
    Attributs du produit
    Human FAP Protein, His Tag (MALS verified) (active enzyme)
    Pureté
    >95 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product FAP Protéine
  • Restrictions
    For Research Use only
  • Format
    Powder
    Buffer
    PBS, pH 7.4
    Stock
    -20 °C
  • Antigène
    FAP (Fibroblast Activation Protein, alpha (FAP))
    Autre désignation
    FAP (FAP Produits)
    Synonymes
    fap-A Protein, gene 13 Protein, FAP Protein, fapa Protein, dppiv Protein, seprase Protein, DPPIV Protein, FAPA Protein, fibroblast activation protein Protein, fibroblast activation protein alpha L homeolog Protein, fibroblast activation protein alpha Protein, fibroblast activation protein, alpha Protein, prolyl endopeptidase FAP Protein, Fap Protein, fap.L Protein, FAP Protein, fap Protein, LOC100547273 Protein
    Sujet
    FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
    Poids moléculaire
    86.9 kDa
    Pathways
    Tube Formation
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