ILDR2 Protein (AA 21-186) (Fc Tag)

N° du produit ABIN7013532

Détail du produit

Antigène: ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))

Type de proteíne: Recombinant

Attributs du protein: AA 21-186

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ILDR2 protéine est marqué à la Fc Tag.

Attributs du produit: Human ILDR2 Protein, Fc Tag

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))

Autre désignation: ILDR2 (ILDR2 Produits)

Synonymes: C1orf32 Protein, RP4-782G3.2 Protein, dJ782G3.1 Protein, immunoglobulin like domain containing receptor 2 Protein, ILDR2 Protein

Sujet: ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

Poids moléculaire: 45.1 kDa

NCBI Accession: NP_955383