FURIN Protein (AA 27-574) (His tag)

N° du produit ABIN7013596

Détail du produit

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Type de proteíne: Recombinant

Attributs du protein: AA 27-574

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette FURIN protéine est marqué à la His tag.

Fonction: Human Furin / PCSK3 Protein, His Tag

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 20 mM Tris, 150 mM NaCl, pH 9.0

Stock: -80 °C

Détail du antigène

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Autre désignation: Furin (FURIN Produits)

Synonymes: FURIN Protein, furin Protein, si:dkey-281a24.5 Protein, FUR Protein, LOC100220259 Protein, PACE Protein, spc1 Protein, xfurin Protein, MGC82710 Protein, PCSK3 Protein, SPC1 Protein, 9130404I01Rik Protein, Fur Protein, Pcsk3 Protein, Pace Protein, furin, paired basic amino acid cleaving enzyme Protein, furin (paired basic amino acid cleaving enzyme) a Protein, furin (paired basic amino acid cleaving enzyme) b Protein, furin, paired basic amino acid cleaving enzyme L homeolog Protein, furin (paired basic amino acid cleaving enzyme) Protein, FURIN Protein, furina Protein, furinb Protein, furin Protein, furin.L Protein, Furin Protein

Sujet: Furin is also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg'). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.

Poids moléculaire: 62.1 kDa

NCBI Accession: NM_002569

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway