Claudin 18.2 (Active) protein (His tag,Twin-Strep tag)

N° du produit ABIN7199139

Détail du produit

Antigène: Claudin 18.2

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Cellules d'insectes

Purification/Conjugué: His tag,Twin-Strep tag

Fonction: Human Claudin-18.2 Protein, His,Twin-Strep Tag (active membrane protein)

Séquence: Met 1 - Ala 200

Attributs du produit: Human Claudin-18.2, His,Twin-Strep Tag (CL2-H5587) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-2).

Pureté: >80 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 20 kDa and 40 kDa under non-reducing (NR) condition due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH 7.5

Stock: -80 °C

Stockage commentaire: -70°C

Détail du antigène

Antigène: Claudin 18.2

Autre désignation:  Claudin-18.2 

Sujet: Synonyms: Claudin-18.2,CLDN18,Claudin-18,
Description: Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

Poids moléculaire: 26.3 kDa

NCBI Accession: NP_001002026