Claudin 18.2 protein (Biotin,His-Avi Tag)
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- Antigène
- Claudin 18.2
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Cellules d'insectes
- Purification/Conjugué
- Biotin,His-Avi Tag
- Fonction
- Biotinylated Human Claudin-18.2 Protein, Avitag™,His Tag (Nanodisc)
- Séquence
- Met 1 - Ala 200
- Attributs du produit
- Biotinylated Human Claudin-18.2 Protein, Avitag,His Tag is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-2).
- niveau d'endotoxine
- 1.0 EU per μg
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Claudin 18.2 (AA 1-261) (Active) protein-VLP
Origine: Humain Hôte: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Func, Imm, SPR Active
Claudin 18.2 (AA 1-261) (Active) protein-VLP (Biotin)Origine: Humain Hôte: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Func, Imm, SPR Active
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- Commentaires
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This protein carries an Avi tag (Avitag™) at the N-terminus, followed by a polyhistidine tag. (Biotin,Avi , 10xHis) The protein has a calculated MW of 24.8 kDa.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 20 mM HEPES, 150 mM NaCl, pH 7.5
- Stock
- -80 °C
- Stockage commentaire
- -70°C
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- Antigène
- Claudin 18.2
- Autre désignation
- Claudin-18.2
- Sujet
- Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
- Poids moléculaire
- 24.8 kDa
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