FOLR2 Protein (His-Avi Tag,Biotin)

N° du produit ABIN7199426

Détail du produit

Antigène: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette FOLR2 protéine est marqué à la His-Avi Tag,Biotin.

Fonction: Biotinylated Human FOLR2 Protein, His,Avitag™

Séquence: Thr 17 - His 228

Attributs du produit: Biotinylated Human FOLR2, His,Avitag (FO2-H82E8) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - His 228 (Accession # P14207-1).

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 28.2 kDa. The protein migrates as 30-40 kDa under reducing (R) condition due to glycosylation.

Commentaires:

Ready-to-use Avitag™ biotinylated protein:
The product is exclusively produced using the Avitag™ technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Autre désignation: FOLR2 (FOLR2 Produits)

Synonymes: FOLR2 Protein, BETA-HFR Protein, FBP Protein, FBP/PL-1 Protein, FR-BETA Protein, FR-P3 Protein, FBP2 Protein, Folbp-2 Protein, Folbp2 Protein, folate receptor 1 Protein, folate receptor beta Protein, folate receptor 2 (fetal) Protein, FOLR1 Protein, FOLR2 Protein, Folr2 Protein

Sujet: Synonyms: FOLR2,BETA-HFR,FBP,PL-1,FR-BETA,FR-P3,FBP,
Description: Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68 % and 79 % sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

Poids moléculaire: 28.2 kDa

Pathways: Dicarboxylic Acid Transport