ITGAV/ITGB6 Protein (His tag)

N° du produit ABIN7121505

Détail du produit

Antigène: ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))

Type de proteíne: Recombinant

Origine: Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: Cette ITGAV/ITGB6 protéine est marqué à la His tag.

Fonction: Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free

Séquence: Phe 31 - Pro 993 (ITGAV) & Gly 22 - Pro 709 (ITGB6)

Attributs du produit: Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (IT6-C52W9) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 993 (ITGAV) & Gly 22 - Pro 709 (ITGB6) (Accession # A0A2K5WCD3-1 (ITGAV) & A0A2K5TZ36-1 (ITGB6).

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 113.1 kDa (ITGAV) and 79.0 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The non-reducing (NR) protein migrates as kDa (ITGAV) & 85-95 kDa (ITGB6) respectively due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 8.0

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))

Autre désignation: Integrin alpha V beta 6 (ITGAV&ITGB6) (ITGAV/ITGB6 Produits)

Sujet: Synonyms: Integrin alpha V beta 6,ITGAV&ITGB6,
Description: Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency-associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

Poids moléculaire: 113.1 kDa (ITGAV) & 79.9 kDa (ITGB6)