ACVR2B Protein (His tag)

N° du produit ABIN7194130

Détail du produit

Antigène: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ACVR2B protéine est marqué à la His tag.

Fonction: Recombinant Human ACVR2B/ActivinR-IIB Protein (His Tag)(Active)

Séquence: Met 1-Thr 134

Attributs du produit: A DNA sequence encoding the extracellular domain of human ACVR2B (NP_001097.2) (Met 1-Thr 134) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 97 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: 1.Measured by its ability to bind biotinylated Human INHBA-his in functional ELISA.2. Measured by its ability to bind biotinylated Mouse INHBA-his in functional ELISA.3. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.3-2 μg/mL in the presence of 10 ng/mL recombinant Activin A.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Autre désignation: ACVR2B/ActivinR-IIB (ACVR2B Produits)

Synonymes: ACVR2B Protein, XAR1 Protein, actr-iib Protein, actriib Protein, ACTRIIB Protein, ActR-IIB Protein, HTX4 Protein, ActRIIB Protein, actr2b Protein, actrIIb Protein, wu:fj97d11 Protein, activin A receptor type 2B Protein, activin A receptor type 2B L homeolog Protein, activin A receptor type 2Ba Protein, activin receptor IIB Protein, ACVR2B Protein, acvr2b Protein, acvr2b.L Protein, Acvr2b Protein, acvr2ba Protein

Sujet:

Background: ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

Synonym: Activin Receptor Type-2B, Activin Receptor Type IIB, ACTR-IIB, ACVR2B,Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-4, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor

Poids moléculaire: 15 kDa

NCBI Accession: NP_001097

Pathways: Hormone Transport, Cancer Immune Checkpoints