ADAM9 Protein (His tag)

N° du produit ABIN7320417

Détail du produit

Antigène: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette ADAM9 protéine est marqué à la His tag.

Fonction: Recombinant Mouse ADAM9 Protein (His Tag)

Séquence: Met 1-Asp 697

Attributs du produit: A DNA sequence encoding the mouse ADAM9 (Q61072) extracellular domain (Met 1-Asp 697) was expressed with a C-terminal polyhistidine tag.

Pureté: > 87 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Autre désignation: ADAM9 (ADAM9 Produits)

Synonymes: CORD9 Protein, MCMP Protein, MDC9 Protein, Mltng Protein, AU020942 Protein, mKIAA0021 Protein, adam9-A Protein, cord9 Protein, mcmp Protein, mltng Protein, Adam9 Protein, zgc:101824 Protein, ADAM9 Protein, ADAM metallopeptidase domain 9 Protein, a disintegrin and metallopeptidase domain 9 (meltrin gamma) Protein, ADAM metallopeptidase domain 9 L homeolog Protein, ADAM9 Protein, Adam9 Protein, adam9.L Protein, adam9 Protein

Sujet:

Background: ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various human cancers, and plays a role in tumorigenesis in mouse models. ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential therapeutic target in tumors where it is highly expressed. ADAM9 belongs to a family of transmembrane, disintegrin-containing metalloproteinases involved in protein ectodomain shedding and cell-cell and cell-matrix interactions. ADAM-9 adhesive domain plays a role in regulating the motility of cells by interaction with beta1 integrins and modulates MMP synthesis.

Synonym: AU020942,MDC9,mKIAA0021,Mltng

Poids moléculaire: 74.9 kDa

UniProt: Q61072

Pathways: Cellular Response to Molecule of Bacterial Origin, SARS-CoV-2 Protein Interactome