BLK Protein (GST tag)

N° du produit ABIN7317084

Détail du produit

Antigène: BLK (B Lymphoid Tyrosine Kinase (BLK))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette BLK protéine est marqué à la GST tag.

Fonction: Recombinant Human BLK Protein (GST Tag)(Active)

Séquence: Met 1-Pro 505

Attributs du produit: A DNA sequence encoding the human BLK (NP_001706.2) (Met 1-Pro 505) was fused with the GST tag at the N-terminus.

Pureté: > 88 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 17.4 nmol/min/mg using Poly(Glu,Tyr)4:1 peptide as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 5 mM GSH, pH 7.4

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: BLK (B Lymphoid Tyrosine Kinase (BLK))

Autre désignation: BLK (BLK Produits)

Synonymes: bltk Protein, si:dkey-33i22.2 Protein, zgc:136231 Protein, MODY11 Protein, BLK proto-oncogene, Src family tyrosine kinase Protein, B lymphoid kinase Protein, blk Protein, BLK Protein, Blk Protein

Sujet:

Background: Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and the high expression levels of Blk in mature B cells suggest a possible important role of Blk in B-cell physiology. It is a modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 which is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Synonym: Tyrosine-Protein Kinase Blk; B Lymphocyte Kinase; p55-Blk; BLK;MODY11

NCBI Accession: NP_001706

Pathways: Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling