CSNK1A1 Protein (GST tag)

N° du produit ABIN7317097

Détail du produit

Antigène: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette CSNK1A1 protéine est marqué à la GST tag.

Fonction: Recombinant Human CSNK1A1/CKI-alpha/CK1 Protein (GST Tag)(Active)

Séquence: Met 1-Phe 337

Attributs du produit: A DNA sequence encoding the full length of human CSNK1A1 isoform 1 (P48729-1) (Met 1-Phe 337) was expressed with the GST tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 30 nmol/min/mg using casein as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, pH 7.4

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Autre désignation: CSNK1A1/CKI-alpha/CK1 (CSNK1A1 Produits)

Synonymes: CK1 Protein, CK1a Protein, CKIa Protein, HLCDGP1 Protein, PRO2975 Protein, 2610208K14Rik Protein, 4632404G05Rik Protein, 5430427P18Rik Protein, Csnk1a Protein, CHUNP6894 Protein, ck1alpha Protein, wu:fb65a02 Protein, wu:fi30h04 Protein, wu:fj19c11 Protein, zgc:92158 Protein, KER1 Protein, ck1 Protein, CKIALPHA Protein, CK-II Protein, CSNK2A1 Protein, CG2028 Protein, CK I Protein, CK1alpha Protein, CKI Protein, CKI alpha Protein, CKIalpha Protein, CkIa Protein, Dmel\\CG2028 Protein, PKA-C Protein, anon-WO03040301.93 Protein, anon-WO03040301.95 Protein, ck1a Protein, dmCK1 Protein, dmckI Protein, l(1)G0492 Protein, casein kinase 1 alpha 1 Protein, casein kinase 1, alpha 1 Protein, keratin 1 Protein, casein kinase 1 alpha 1 L homeolog Protein, casein kinase 2 alpha 1 Protein, Casein kinase Ialpha Protein, CSNK1A1 Protein, Csnk1a1 Protein, csnk1a1 Protein, KRT1 Protein, csnk1a1.L Protein, CSNK2A1 Protein, CkIalpha Protein

Sujet:

Background: Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.

Synonym: CK1;CK1a;CKIa;HEL-S-77p;HLCDGP1;PRO2975

Poids moléculaire: 65.2 kDa

Pathways: Signalisation WNT, Signalisation Hedgehog