CHI3L2 Protein (His tag)

N° du produit ABIN7319652

Détail du produit

Antigène: CHI3L2 (Chitinase 3-Like 2 (CHI3L2))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette CHI3L2 protéine est marqué à la His tag.

Fonction: Recombinant Human CHI3L2/YKL-39 Protein (His Tag)

Séquence: Tyr27-Leu390

Attributs du produit: Recombinant Human Chitinase 3-Like Protein 2 is produced by our Mammalian expression system and the target gene encoding Tyr27-Leu390 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CHI3L2 (Chitinase 3-Like 2 (CHI3L2))

Autre désignation: CHI3L2/YKL-39 (CHI3L2 Produits)

Synonymes: CHIL2 Protein, YKL-39 Protein, YKL39 Protein, chitinase 3 like 2 Protein, CHI3L2 Protein

Sujet:

Background: Chitinase 3-Like Protein 2 (CHI3L2) is a 39 kDa secreted glycoprotein which belongs to the glycosyl hydrolase 18 family and the most closely related to human cartilage glycoprotein 39, which promotes the growth of human synovial cells as well as skin and fetal lung fibroblasts. Highest expression of CHI3L2 is in chondrocytes, followed by synoviocytes, lung and heart. It is not detected in spleen, pancreas, and liver. CHI3L2 may also be expressed in developing brain and placenta. Increased levels of CHI3L2 have been demonstrated in synovial fluids of patients with rheumatoid or osteoarthritis as well as in some other pathologies and in malignant tumors, particularly in glioblastomas. CHI3L2 may bind glycan structure with high affinity, but not heparin. It has has no chitotriosidase activity, but is likely to bind some type of glycan.

Synonym: Chitinase-3-Like Protein 2, Chondrocyte Protein 39, YKL-39, CHI3L2,CHIL2,YKL-39,YKL39

Poids moléculaire: 41.94 kDa

UniProt: Q15782