FOLR1 Protein (AA 1-231) (His tag)

N° du produit ABIN7320227

Détail du produit

Antigène: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-231

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette FOLR1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse FOLR1 Protein (aa 1-231, His Tag)

Séquence: Met 1-Met 231

Attributs du produit: A DNA sequence encoding the mouse FOLR1 (NP_032060.2) (Met 1-Met 231) without the pro peptide was expressed, with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Autre désignation: FOLR1 (FOLR1 Produits)

Synonymes: FBP Protein, FOLR Protein, fbp Protein, folr Protein, folr1 Protein, FBP1 Protein, Folbp-1 Protein, Folbp1 Protein, Fbp1 Protein, FOLR1 Protein, Folr1 Protein, folate receptor 1 Protein, folate receptor 1 (adult) Protein, folate receptor 1 (adult) L homeolog Protein, zgc:165502 Protein, Folate receptor alpha Protein, folate receptor alpha Protein, FOLR1 Protein, folr1 Protein, folr1.L Protein, zgc:165502 Protein, Folr1 Protein, LOC100066084 Protein, LOC100725439 Protein

Sujet:

Background: The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. Folate receptor α (FRα) is the most important subunit of Folate receptor and the alpha isoform has been shown to be selectively overexpressed in cancer types like breast and ovarian cancer compared to normal breast and ovarian epithelial cells. It was determined that Folate receptor α exhibits a limited expression on the apical surfaces of the epithelial cells of normal lung, breast, thyroid, parathyroid, and kidney tissues. For their uptake of folate, normal cells rely almost exclusively on the reduced folate carrier, whereas many carcinomas and myeloid leukemia cells overexpress a high-affinity FR on their surfaces, perhaps reflecting their increased need for folate to support rapid cell divisionImmune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: Adult folate-binding protein; FBP; folate binding protein; folate receptor 1 (adult); Folate receptor 1; folate receptor alpha; Folate receptor, adult; Folbp1; FOLR; FOLR1; FR-alpha; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18;FBP1;Folbp-1

Poids moléculaire: 25.6 kDa

NCBI Accession: NP_032060

Pathways: Dicarboxylic Acid Transport