GRK6 Protein (GST tag,His tag)

N° du produit ABIN7317064

Détail du produit

Antigène: GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette GRK6 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human GRK6/GPRK6 Protein (His & GST Tag)(Active)

Séquence: Met 1-Arg 589

Attributs du produit: A DNA sequence encoding the human GRK6 isofrom B (P43250-2) (Met 1-Arg 589) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 93 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 7 nmol/min/mg using casein as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, 0.5 mM PMSF, pH 7.4

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))

Autre désignation: GRK6/GPRK6 (GRK6 Produits)

Synonymes: MGC83187 Protein, GRK6 Protein, GPRK6 Protein, Gprk6 Protein, G protein-coupled receptor kinase 6 Protein, G protein-coupled receptor kinase 6 S homeolog Protein, GRK6 Protein, grk6.S Protein, grk6 Protein, Grk6 Protein

Sujet:

Background: G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6 and GPRK6, is a lipid-anchor protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK subfamily. GRK6 / GPRK6 contains one AGC-kinase C-terminal domain, one protein kinase domain and one RGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described. GRK6 / GPRK6 is widely expressed. GRK6 / GPRK6 silencing causes suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation associated with reduction in MCL1 levels and phosphorylation, illustrating a potent mechanism for the cytotoxicity of GRK6 inhibition in multiple myeloma (MM) tumor cells. GRK6 also appears to be involved in responses to morphine. Inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.

Synonym: GPRK6

Poids moléculaire: 95.1 kDa

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Negative Regulation of Transporter Activity