GPC1 Protein (His tag)

N° du produit ABIN7320535

Détail du produit

Antigène: GPC1 (Glypican 1 (GPC1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette GPC1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse Glypican-1/GPC1 Protein (His Tag)(Active)

Séquence: Asp24-Ser529

Attributs du produit: Recombinant Mouse Glypican-1 is produced by our Mammalian expression system and the target gene encoding Asp24-Ser529 is expressed with a 6His tag at the C-terminus.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human FGFb(Cat: PKSH032437) at 2μg/ml(100 μl/well) can bind Mouse GPC1-His. The ED50 of Mouse GPC1-His is 786 ng/ml .

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GPC1 (Glypican 1 (GPC1))

Autre désignation: Glypican-1/GPC1 (GPC1 Produits)

Synonymes: gpc1 Protein, zgc:63947 Protein, GPC1 Protein, Glypican-1 Protein, glypican Protein, AI462976 Protein, HSPG M12 Protein, HSPGM12 Protein, glypican 1b Protein, glypican 1 Protein, gpc1b Protein, GPC1 Protein, gpc1 Protein, Gpc1 Protein

Sujet:

Background: Glypican-1 is a cell membrane protein and belongs to the glypican family. The protein may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. It is required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.

Synonym: Glypican-1,Gpc1

Poids moléculaire: 56.7 kDa

UniProt: Q9QZF2

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation