IGFBP5 Protein (His tag)

N° du produit ABIN7320561

Détail du produit

Antigène: IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette IGFBP5 protéine est marqué à la His tag.

Fonction: Recombinant Mouse IGFBP-5/IGFBP5 Protein (His Tag)

Séquence: Leu20-Glu271

Attributs du produit: Recombinant Mouse Insulin-like growth factor-binding protein 5 is produced by our Mammalian expression system and the target gene encoding Leu20-Glu271 is expressed with a 6His tag at the C-terminus.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))

Autre désignation: IGFBP-5/IGFBP5 (IGFBP5 Produits)

Synonymes: IBP5 Protein, AI256729 Protein, AW208790 Protein, IGFBP-5 Protein, IGFBP-5P Protein, IGF-BP5 Protein, igfbp5 Protein, ibp5 Protein, IBP-5 Protein, xIGFBP-5 Protein, IGFBP5 Protein, igfbp5b Protein, zgc:165472 Protein, insulin like growth factor binding protein 5 Protein, insulin-like growth factor binding protein 5 Protein, insulin like growth factor binding protein 5 L homeolog Protein, insulin-like growth factor binding protein 5b Protein, insulin-like growth factor-binding protein 5 Protein, insulin-like growth factor binding protein 5a Protein, IGFBP5 Protein, Igfbp5 Protein, igfbp5.L Protein, igfbp5b Protein, igfbp5 Protein, LOC100194500 Protein, igfbp5a Protein

Sujet:

Background: Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. Mouse IGFBP-5 shows 97 % aa sequence identity with those of human and rat IGFBP-5. It is expressed mostly in kidney, uterus and gastrocnemius muscle. It also expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. IGFBP-5 has a strong affinity for hydroxyapatite, allowing it to bind to bone cells. When bound to extracelluar matrix, IGFBP-5 is protected from proteolysis and potentiates IGF activity, but when it is soluble, IGFBP-5 is cleaved to a biologically inactive 21 kDa fragment. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Synonym: BP-5, IGFBP-5, IGF-binding protein 5, Insulin-like growth factor-binding protein 5,

Poids moléculaire: 29.3 kDa

UniProt: Q07079

Pathways: Signalisation WNT, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding