MAP2K4 Protein (GST tag,His tag)

N° du produit ABIN7320204

Détail du produit

Antigène: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Type de proteíne: Recombinant

Origine: Souris

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette MAP2K4 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Mouse MEK4/MAP2K4 Protein (His & GST Tag)

Séquence: Ala 2-Asp 397

Attributs du produit: A DNA sequence encoding the mouse MAP2K4 (P47809) (Ala 2-Asp 397) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Autre désignation: MEK4/MAP2K4 (MAP2K4 Produits)

Synonymes: JNKK Protein, JNKK1 Protein, MAPKK4 Protein, MEK4 Protein, MKK4 Protein, PRKMK4 Protein, SAPKK-1 Protein, SAPKK1 Protein, SEK1 Protein, SERK1 Protein, SKK1 Protein, Sek1 Protein, Serk1 Protein, MKK4A-l Protein, map2k4 Protein, zgc:136500 Protein, jnkk Protein, mek4 Protein, mkk4 Protein, sek1 Protein, jnkk1 Protein, serk1 Protein, xmek2 Protein, mapkk4 Protein, prkmk4 Protein, 142758_at Protein, CG9738 Protein, CT27508 Protein, D-MKK4 Protein, DMKK4 Protein, Dmel\\CG9738 Protein, JNKK2 Protein, Mpk4 Protein, SEK1/MKK4 Protein, dMKK4 Protein, dMkk4 Protein, hep Protein, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 Protein, ATMEK4 Protein, ATMKK4 Protein, F19C24.26 Protein, F19C24_26 Protein, MAP KINASE KINASE 4 Protein, mitogen-activated protein kinase kinase 4 Protein, MKK4B Protein, zgc:194486 Protein, mitogen-activated protein kinase kinase 4 Protein, mitogen-activated protein kinase kinase 4a Protein, MAP kinase kinase 4 Protein, mitogen activated protein kinase kinase 4 Protein, mitogen-activated protein kinase kinase 4b Protein, MAP2K4 Protein, Map2k4 Protein, map2k4a Protein, map2k4 Protein, Mkk4 Protein, MKK4 Protein, map2k4b Protein

Sujet:

Background: Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK and MAP2K4, is a protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase which is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / JNKK1 has been shown to activate MAPK8 / JNK1, MAPK9 / JNK2, and MAPK14 / p38, but not MAPK1 / ERK2 or MAPK3 / ERK1. MAP2K4 / JNKK1 is phosphorylated, and thus activated by MAP3K1 / MEKK. The stress-activated protein kinase (SAPK) pathways represent phosphorylation cascades that convey pro-apoptotic signals. The mitogen-activated protein kinase kinase (MAPKK) homolog MAP2K4 ( MKK4, SEK, JNKK1 ) is a centrally-placed mediator of the SAPK pathways.

Synonym: JNKK1;MEK4;MKK4;PRKMK4;Sek1;Serk1

Poids moléculaire: 72 kDa

UniProt: P47809

Pathways: Signalisation MAPK, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling