MAPKAP Kinase 3 Protein (GST tag)

N° du produit ABIN7317094

Détail du produit

Antigène: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette MAPKAP Kinase 3 protéine est marqué à la GST tag.

Fonction: Recombinant Human MAPKAPK3 Protein (GST Tag)

Séquence: Met 1-Gln 382

Attributs du produit: A DNA sequence encoding the full length of human MAPKAPK3 (NP_004626.1) (Met 1-Gln 382) was expressed with the GST tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 7.5, 0.25 mM DTT, 0.1 mM EDTA, 0.5 mM PMSF, 10 % glycerol

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Autre désignation: MAPKAPK3 (MAPKAPK3 Produits)

Synonymes: 3PK Protein, MAPKAP-K3 Protein, MAPKAP3 Protein, MAPKAPK-3 Protein, MK-3 Protein, AI874665 Protein, MK3 Protein, MapkKapk3 Protein, MAPKAPK3 Protein, mapkapk3 Protein, MGC154360 Protein, 3pk Protein, mapkap3 Protein, zgc:158342 Protein, mitogen-activated protein kinase-activated protein kinase 3 Protein, mitogen-activated protein kinase-activated protein kinase 3 S homeolog Protein, MAPKAPK3 Protein, Mapkapk3 Protein, mapkapk3.S Protein, mapkapk3 Protein

Sujet:

Background: The MAPKAP kinases are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is Widely expressed in human tissues, with a higher expression level observed in heart and skeletal muscle. No expression in brain. MAPKAPK-3 is unique since it was shown to be activated by three members of the MAPK family, namely extracellular-signal-regulated kinase (ERK), p38, and Jun-N-terminal kinase (JNK). It is highly activated both by mitogens and by stress-inducing agents or proinflammatory cytokines, and translocates to the cytoplasm from nucleus. MAPKAPK-3 is exclusively activated via the classical MAPK cascade, while stress-induced activation of MAPKAPK-3 is mainly mediated by p38, however the mechanism defining the specificity remains unknown.

Synonym: 3PK,MAPKAP-K3,MAPKAP3,MAPKAPK-3,MK-3

Poids moléculaire: 69 kDa

NCBI Accession: NP_004626

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades