Neurexin 3 Protein (NRXN3) (His tag)

N° du produit ABIN7317470

Détail du produit

Antigène: Neurexin 3 (NRXN3)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Neurexin 3 protéine est marqué à la His tag.

Fonction: Recombinant Human NRXN3 Protein (His Tag)(Active)

Séquence: Met 1-Thr 357

Attributs du produit: A DNA sequence encoding the human NRXN3 beta isoform 2 (NP_620426.2) extracellular domain (Met 1-Thr 357) was expressed, with a polyhistidine tag at the C-terminus.

Pureté: > 94 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. When 5 x 10E4 cells/well are added to NRXN3 coated plates (0.8 μg/ml and 100 μl/well), approximately 30%-50% will adhere specifically after 60 minutes at 37 °C.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Neurexin 3 (NRXN3)

Autre désignation: NRXN3 (NRXN3 Produits)

Synonymes: C14orf60 Protein, NRXN3 Protein, NRXNIII Protein, im:7144250 Protein, nrxn3aa Protein, nrxn3ab Protein, wu:fj54c11 Protein, neurexin 3 Protein, neurexin III Protein, neurexin-3 Protein, neurexin 3a Protein, neurexin 3b Protein, NRXN3 Protein, Nrxn3 Protein, nrxn3 Protein, LOC490812 Protein, nrxn3a Protein, nrxn3b Protein

Sujet:

Background: Neurexin-3-beta; also known as Neurexin III-beta and NRXN3; is a single-pass type I  membrane protein which belongs to the neurexin family. It contains one laminin G-like domain. It is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion. Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two; NRXN1 and NRXN3; are among the largest known human genes. Three of the genes ( NRXN1; NRXN2; NRXN3 ) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain EGF-like sequences and laminin G domains; and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction; or obesity.

Synonym: C14orf60

Poids moléculaire: 36 kDa

NCBI Accession: NP_620426