TRKB Protein (Fc Tag)

N° du produit ABIN7197179

Détail du produit

Antigène: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette TRKB protéine est marqué à la Fc Tag.

Fonction: Recombinant Rat TrkB/NTRK2 Protein (Fc Tag)

Séquence: Met1-His429

Attributs du produit: A DNA sequence encoding the Rat NTRK2 (NP_036863) (Met1-His429) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Pureté: > 92 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Autre désignation: TrkB/NTRK2 (NTRK2 Produits)

Synonymes: trkb Protein, trkb-b Protein, xtrkb Protein, si:ch211-220b11.1 Protein, trkB2 Protein, NTRK2 Protein, ntrk2 Protein, gp145-trkb Protein, TRKB Protein, GP145-TrkB Protein, trk-B Protein, AI848316 Protein, C030027L06Rik Protein, Tkrb Protein, trkB Protein, RATTRKB1 Protein, TRKB1 Protein, Trk-B Protein, TrkB Protein, neurotrophic receptor tyrosine kinase 2 Protein, neurotrophic receptor tyrosine kinase 2 L homeolog Protein, neurotrophic tyrosine kinase, receptor, type 2b Protein, neurotrophic receptor tyrosine kinase 2 S homeolog Protein, neurotrophic tyrosine kinase, receptor, type 2 Protein, NTRK2 Protein, ntrk2.L Protein, ntrk2b Protein, ntrk2.S Protein, ntrk2 Protein, Ntrk2 Protein

Sujet:

Background: TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: NTRK2;Trkb

Poids moléculaire: 71.5 kDa

NCBI Accession: NP_036863

Pathways: Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport