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OMG Protein (AA 1-416) (His tag)

OMG Origine: Humain Hôte: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7317937
  • Antigène Voir toutes OMG Protéines
    OMG (Oligodendrocyte Myelin Glycoprotein (OMG))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 1-416
    Origine
    • 4
    • 3
    Humain
    Source
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette OMG protéine est marqué à la His tag.
    Fonction
    Recombinant Human OMGP/OMG Protein (aa 1-416, His Tag)(Active)
    Séquence
    Met 1-Pro 416
    Attributs du produit
    A DNA sequence encoding the mature form of human OMGP (P23515-1) (Met 1-Pro 416) without the pro peptide was expressed, fused with a polyhistidine tag at the C-terminus.
    Pureté
    > 97 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. Immobilized OMG (0.8 μg/ml, 100 μl/well) will mediate >15% C6 cell adhesion.
    Top Product
    Discover our top product OMG Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    OMG (Oligodendrocyte Myelin Glycoprotein (OMG))
    Autre désignation
    OMGP/OMG (OMG Produits)
    Synonymes
    OMGP Protein, omgp Protein, MGC107958 Protein, OMG Protein, DKFZp459F1351 Protein, oligodendrocyte myelin glycoprotein Protein, myelin oligodendrocyte glycoprotein Protein, oligodendrocyte-myelin glycoprotein Protein, OMG Protein, MOG Protein, Omg Protein, omg Protein
    Sujet

    Background: Oligodendrocyte-myelin glycoprotein; also known as OMG and OMGP; is a cell membrane protein which contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR; the receptor for Nogo. This function requires its leucine-rich repeat domain; a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation; neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.

    Synonym: OMGP

    Poids moléculaire
    46 kDa
    Pathways
    Neurotrophin Signaling Pathway, Regulation of Cell Size
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