OMG Protein (AA 1-245) (His tag)

N° du produit ABIN7320193

Détail du produit

Antigène: OMG (Oligodendrocyte Myelin Glycoprotein (OMG))

Type de proteíne: Recombinant

Attributs du protein: AA 1-245

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette OMG protéine est marqué à la His tag.

Fonction: Recombinant Mouse OMGP/OMG Protein (aa 1-245, His Tag)

Séquence: Met 1-Thr 245

Attributs du produit: A DNA sequence encoding the amino acids (Met 1-Thr 245) of mouse OMGP (Q63912) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: OMG (Oligodendrocyte Myelin Glycoprotein (OMG))

Autre désignation: OMGP/OMG (OMG Produits)

Synonymes: OMGP Protein, omgp Protein, MGC107958 Protein, OMG Protein, DKFZp459F1351 Protein, oligodendrocyte myelin glycoprotein Protein, myelin oligodendrocyte glycoprotein Protein, oligodendrocyte-myelin glycoprotein Protein, OMG Protein, MOG Protein, Omg Protein, omg Protein

Sujet:

Background: Oligodendrocyte-myelin glycoprotein, also known as OMG and OMGP, is a cell membrane protein which contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR, the receptor for Nogo. This function requires its leucine-rich repeat domain, a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation, neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.

Synonym: RP23-67E18.6, LNGFR, Tnfrsf16, p75, p75NGFR, p75NTR

Poids moléculaire: 27 kDa

UniProt: Q63912

Pathways: Neurotrophin Signaling Pathway, Regulation of Cell Size