RAC2 Protein (His tag)

N° du produit ABIN7317414

Détail du produit

Antigène: RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RAC2 protéine est marqué à la His tag.

Fonction: Recombinant Human RAC2 Protein (His Tag)

Séquence: Met 1-Cys 189

Attributs du produit: A DNA sequence encoding the human RAC2 (P15153) (Met 1-Cys 189) was expressed, with a polyhistidine tag at the N-terminus.

Pureté: > 94 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 20 % glycerol, pH 7.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2))

Autre désignation: RAC2 (RAC2 Produits)

Synonymes: rac2 Protein, AI323801 Protein, AI452260 Protein, EN-7 Protein, Gx Protein, HSPC022 Protein, p21-Rac2 Protein, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) Protein, RAS-related C3 botulinum substrate 2 Protein, Rac family small GTPase 2 Protein, rac2 Protein, Rac2 Protein, RAC2 Protein

Sujet:

Background: Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is attached to the small G-protein, the enzyme is inactivated. Release of the GDP and replace of the GTP cativate the GTPasee. Rac2 remains active until the GTP is hydrolyzed to GDP. Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADPH oxidase complex and shares 92% amino acid identity with the ubiquitously expressed Rac1. The small G-protein Rac2 regulates the rearrangements of actin and membrane necessary for Fcy receptor-mediated phagocytosis by macrophages. Activated Rac2 binds to the p21-binding domain of PAK1 and this binding provided a basis for microscopic methods to localize activation of these G proteins inside cells.

Synonym: EN-7;Gx;HSPC022;p21-Rac2

Poids moléculaire: 22.6 kDa

UniProt: P15153

Pathways: Signalisation RTK, VEGF Signaling