ROR1 Protein (AA 453-783) (GST tag,His tag)

N° du produit ABIN7317047

Détail du produit

Antigène: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 453-783

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette ROR1 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human ROR1 Protein (aa 453-783, His & GST Tag)(Active)

Séquence: Met 453-Asn783

Attributs du produit: A DNA sequence encoding the human ROR1 (AAA60275.1) (Met453-Asn783) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 0.3 nmol/min/mg using MBP as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, 3 mM DTT, 10 % glycerol, pH 7.4

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Autre désignation: ROR1 (ROR1 Produits)

Synonymes: NTRKR1 Protein, dJ537F10.1 Protein, 2810404D04Rik Protein, Ntrkr1 Protein, mRor1 Protein, RGD1559469 Protein, ROR1 Protein, fi34e02 Protein, si:dkey-209n16.1 Protein, wu:fi34e02 Protein, receptor tyrosine kinase like orphan receptor 1 Protein, receptor tyrosine kinase-like orphan receptor 1 Protein, ROR1 Protein, Ror1 Protein, ror1 Protein

Sujet:

Background: Receptor tyrosine kinase-like orphan receptor 1 (ROR1), also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. At developmental stage, it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Synonym: dJ537F10.1,NTRKR1

Poids moléculaire: 65.3 kDa

Pathways: Signalisation RTK, Signalisation WNT, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha