SLAMF1 Protein (His tag)

N° du produit ABIN7317747

Détail du produit

Antigène: SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette SLAMF1 protéine est marqué à la His tag.

Fonction: Recombinant Human CD150/SLAMF1 Protein (His Tag)(Active)

Séquence: Met 1-Pro 258

Attributs du produit: A DNA sequence encoding the human SLAM (NP_003028.1) precursor (Met 1-Pro 258) with a C-terminal polyhistidine tag was expressed.

Pureté: > 97 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1))

Autre désignation: CD150/SLAMF1 (SLAMF1 Produits)

Synonymes: CD150 Protein, SLAM Protein, SLAMF1 Protein, 4933415F16 Protein, AA177906 Protein, CDw150 Protein, ESTM51 Protein, IPO-3 Protein, Slam Protein, RGD1560634 Protein, signaling lymphocytic activation molecule family member 1 Protein, SLAMF1 Protein, Slamf1 Protein

Sujet:

Background: CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.

Synonym: Signaling Lymphocytic Activation Molecule, CDw150, IPO-3, CD150, SLAMF1, SLAM

Poids moléculaire: 25.8 kDa

NCBI Accession: NP_003028