TLR2 Protein (AA 1-587) (His tag)

N° du produit ABIN7318056

Détail du produit

Antigène: TLR2 (Toll-Like Receptor 2 (TLR2))

Type de proteíne: Recombinant

Attributs du protein: AA 1-587

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette TLR2 protéine est marqué à la His tag.

Fonction: Recombinant Human TLR2/CD282 Protein (aa 1-587, His Tag)

Séquence: Met 1-Arg 587

Attributs du produit: A DNA sequence encoding the human TLR2 (O60603) extracellular domain (Met 1-Arg 587) was expressed, with a polyhistidine tag at the C-terminus.

Pureté: > 85 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TLR2 (Toll-Like Receptor 2 (TLR2))

Autre désignation: TLR2/CD282 (TLR2 Produits)

Synonymes: CD282 Protein, TIL4 Protein, Ly105 Protein, toll like receptor 2 Protein, toll-like receptor 2 Protein, TLR2 Protein, Tlr2 Protein, tlr2 Protein

Sujet:

Background: TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathogen recognition and activation of innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 contains 14 LRR (leucine-rich) repeats and 1 TIR domain. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. CD282 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. CD282 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It may also promote apoptosis in response to lipoproteins.

Synonym: CD282,TIL4

Poids moléculaire: 65.8kDa

UniProt: O60603

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades