TPSAB1 Protein (His tag)

N° du produit ABIN7319118

Détail du produit

Antigène: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette TPSAB1 protéine est marqué à la His tag.

Fonction: Recombinant Human TPSAB1 Protein (His Tag)

Séquence: Ile31-Pro275

Attributs du produit: Recombinant Human Tryptase alpha/beta-1 is produced by our Mammalian expression system and the target gene encoding Ile31-Pro275 is expressed with a 6His tag at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Autre désignation: TPSAB1 (TPSAB1 Produits)

Synonymes: TPS1 Protein, TPS2 Protein, TPSB1 Protein, PMCT7 Protein, tpsab1 Protein, tryptaseB Protein, tryptaseC Protein, MMCP-7 Protein, Mcp-7 Protein, Mcp7 Protein, Mcpt7 Protein, rMCP-7 Protein, AV011504 Protein, MMCP-6 Protein, Mcp-6 Protein, Mcp6 Protein, Mcpt6 Protein, tryptase alpha/beta 1 Protein, tryptase Protein, tryptase beta 2 (gene/pseudogene) Protein, tryptase beta 2 Protein, TPSAB1 Protein, MCT7 Protein, tpsab1 Protein, TPSB2 Protein, Tpsab1 Protein, Tpsb2 Protein

Sujet:

Background: Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin, in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates. It may play a role in innate immunity.

Synonym: tryptase alpha/beta 1,Tryptase 1,TPS1, TPS2, TPSAB1, TPSB1

Poids moléculaire: 28.8 kDa

UniProt: Q15661