Annexin A2 Protein (ANXA2) (AA 2-339) (His tag)

N° du produit ABIN7273844

Détail du produit

Antigène: Annexin A2 (ANXA2)

Type de proteíne: Recombinant

Attributs du protein: AA 2-339

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Annexin A2 protéine est marqué à la His tag.

Fonction: Human ANXA2 Protein

Séquence: Ser2-Asp339

Attributs du produit: Recombinant Human ANXA2 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Ser2-Asp339.

Pureté: > 95 % as determined by Tris-Bis PAGE

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Annexin A2 (ANXA2)

Autre désignation: ANXA2 (ANXA2 Produits)

Synonymes: ANX2 Protein, ANX2L4 Protein, CAL1H Protein, LIP2 Protein, LPC2 Protein, LPC2D Protein, P36 Protein, PAP-IV Protein, AW215814 Protein, Cal1h Protein, p36 Protein, anx2 Protein, lip2 Protein, lpc2 Protein, cal1h Protein, lpc2d Protein, pap-i Protein, anx2l4 Protein, MGC76145 Protein, ANXA2 Protein, anxa2 Protein, anxa2-a Protein, anxa2-b Protein, annexin A2 Protein, annexin A2 S homeolog Protein, ANXA2 Protein, Anxa2 Protein, anxa2 Protein, anxa2.S Protein

Sujet: ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.

Poids moléculaire: 39.6 kDa same as Tris-Bis PAGE result.

UniProt: P07355

Pathways: S100 Proteins