IFNA1 Protein (AA 24-189) (Fc Tag)

N° du produit ABIN7274845

Détail du produit

Antigène: IFNA1 (Interferon, alpha 1 (IFNA1))

Type de proteíne: Recombinant

Attributs du protein: AA 24-189

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IFNA1 protéine est marqué à la Fc Tag.

Fonction: Human IFN alpha 1 Protein

Séquence: Cys24-Glu189

Attributs du produit: Recombinant Human IFN alpha 1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Cys24-Glu189.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 0.12 μM as determined in SPR assay (Biacore T200). See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: IFNA1 (Interferon, alpha 1 (IFNA1))

Autre désignation: IFN alpha 1 (IFNA1 Produits)

Synonymes: IFL Protein, IFN Protein, IFN-ALPHA Protein, IFN-alphaD Protein, IFNA13 Protein, IFNA@ Protein, Ifa1 Protein, IFN-ALPHA-1 Protein, IFN1@ Protein, IFNA1 Protein, IFN-alpha Protein, IFN-gamma Protein, IFNA Protein, IFNA2 Protein, IFNA6 Protein, IFN-alpha1 Protein, interferon alpha 13 Protein, interferon alpha 1 Protein, interferon, alpha 1 Protein, interferon, alpha 13 Protein, interferon Protein, interferon-alpha 1 Protein, interferon, alpha, leukocyte Protein, interferon-alpha-14 Protein, IFNA13 Protein, IFNA1 Protein, Ifna1 Protein, ifna1 Protein, IFNA3 Protein, IFN-ALPHA-14 Protein

Sujet: IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.

Poids moléculaire: 46.14 kDa. Due to glycosylation, the protein migrates to 48-55 kDa based on Tris-Bis PAGE result.

UniProt: P01562

Pathways: Signalistation JAK/STAT, Hepatitis C