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NOTCH3 Protein (His-Avi Tag)

NOTCH3 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
N° du produit ABIN7275366
  • Antigène Voir toutes NOTCH3 Protéines
    NOTCH3 (Notch 3 (NOTCH3))
    Type de proteíne
    Recombinant
    Origine
    • 12
    • 5
    Humain
    Source
    • 8
    • 5
    • 3
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette NOTCH3 protéine est marqué à la His-Avi Tag.
    Séquence
    Ala40-Glu467
    Pureté
    > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1EU per μg by the LAL method.
    Top Product
    Discover our top product NOTCH3 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    NOTCH3 (Notch 3 (NOTCH3))
    Autre désignation
    Notch 3 (NOTCH3 Produits)
    Synonymes
    CADASIL Protein, CASIL Protein, IMF2 Protein, AW229011 Protein, N3 Protein, hpbk Protein, fa14b08 Protein, notch5 Protein, wu:fa14b08 Protein, notch 3 Protein, NOTCH3 Protein, Notch3 Protein, notch3 Protein
    Sujet
    CADASIL, Notch homolog 3, Notch-3, NOTCH3,Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
    Poids moléculaire
    47.7 kDa. Due to glycosylation, the protein migrates to 53-60 kDa based on Tris-Bis PAGE result.
    UniProt
    Q9UM47
    Pathways
    Signalisation Notch
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