Oncostatin M Receptor Protein (OSMR) (AA 28-737) (His tag)

N° du produit ABIN7275383

Détail du produit

Antigène: Oncostatin M Receptor (OSMR)

Type de proteíne: Recombinant

Attributs du protein: AA 28-737

Origine: Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: Cette Oncostatin M Receptor protéine est marqué à la His tag.

Fonction: Cynomolgus OSMR Protein

Séquence: Glu28-Ser737

Attributs du produit: Recombinant Cynomolgus OSMR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu28-Ser737.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Cynomolgus OSMR, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 14.4ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Oncostatin M Receptor (OSMR)

Autre désignation: OSMR (OSMR Produits)

Synonymes: OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein

Sujet: OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.

Poids moléculaire: 82.04 kDa. Due to glycosylation, the protein migrates to 110-130 kDa based on Tris-Bis PAGE result.

UniProt: A0A2K5UFW5

Pathways: Signalistation JAK/STAT, Growth Factor Binding