Oncostatin M Receptor Protein (OSMR) (AA 28-740) (His tag)
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- Antigène Voir toutes Oncostatin M Receptor (OSMR) Protéines
- Oncostatin M Receptor (OSMR)
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 28-740
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Oncostatin M Receptor protéine est marqué à la His tag.
- Fonction
- Human OSMR Protein
- Séquence
- Glu28-Met740
- Attributs du produit
- Recombinant Human OSMR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu28-Met740.
- Pureté
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human OSMR, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 4.4ng/ml determined by ELISA. See testing image for detail.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- Oncostatin M Receptor (OSMR)
- Autre désignation
- OSMR (OSMR Produits)
- Synonymes
- OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein
- Sujet
- OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.
- Poids moléculaire
- 82.2 kDa. Due to glycosylation, the protein migrates to 110-140 kDa based on Tris-Bis PAGE result.
- Pathways
- Signalistation JAK/STAT, Growth Factor Binding
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